In a second study, Arev Sümer (also of the Max Planck Institute) and her colleagues found something very similar in the genomes of people who lived 49,500 to 41,000 years ago in what’s now the area around Ranis, Germany. The Ranis population, based on how their genomes compare to other ancient and modern people, seem to have been part of one of the first groups to split off from the wave of humans who migrated out of Africa, through the Levant, and into Eurasia sometime around 50,000 years ago. They carried with them traces of what their ancestors had gotten up to during that journey: about 2.9 percent of their genomes were made up of segments of Neanderthal ancestry.

Based on how long the Ranis people’s segments of Neanderthal DNA were (longer chunks of Neanderthal ancestry tend to point to more recent mixing), the interspecies mingling happened about 80 generations, or about 2,300 years, before the Ranis people lived and died. That’s about 49,000 to 45,000 years ago. The dates from both studies line up well with each other and with archaeological evidence that points to when Neanderthal and Homo sapiens cultures overlapped in parts of Europe and Asia.

What’s still not clear is whether that period of contact lasted the full 5,000 to 7,000 years, or if, as Johannes Krause (also of the Max Planck Institute) suggests, it was only a few centuries—1,500 years at the most—that fell somewhere within that range of dates.

Natural selection worked fast on our borrowed Neanderthal DNA

Once those first Homo sapiens in Eurasia had acquired their souvenir Neanderthal genes (forget stealing a partner’s hoodie; just take some useful segments of their genome), natural selection got to work on them very quickly, discarding some and passing along others, so that by about 100 generations after the “event,” the pattern of Neanderthal DNA segments in people’s genomes looked a lot like it does today.

https://arstechnica.com/science/2024/12/studies-pin-down-exactly-when-humans-and-neanderthals-swapped-dna/