Directed by Noam Murro and aided by production agencies Prodigious France, PXP, Le Pac, and Boogie Films and post-production agencies including Le Pac and Mathematic, the ad ostensibly serves as a celebration of Pfizer’s last 175 years. After Pfizer’s roughly $43 billion acquisition of cancer-focused biotechnology company Seagen Inc. and its cancer-cell-killing antibody-drug conjugate, cancer became a Super Bowl-sized priority for the company.

It announced a three-year, $15 million partnership with the American Cancer Society to target breast and prostate cancer in underserved communities. Pfizer said it’s doubling its oncology capacity, developing 50 new programs and 27 new molecular entities, and dedicating roughly 40% of all its research and development to cancer.

Pfizer’s Super Bowl ad debut during a year in which 30-second spots start at roughly $7 million won’t have its return-on-investment measured in sales. But beyond site visits, social media engagement and overall awareness, the company hopes the spot drives increased urgency around cancer throughout its industry.

“Great brands do not always make other communications around ‘Buy something,’” Panayiotou said. “Great brands create movements and, here, we want to create a movement around cancer across the community.”

Even as deaths from cancer in the U.S. have decreased 33% since the 1990s, the American Cancer Society noted that an aging, growing population is leading to a rise in overall diagnoses. Those same factors will yield 28.4 million new cancer cases around the world by 2040, while one in three people in the U.S. will be diagnosed with cancer in their lifetime.

“The ecosystem around a person who gets cancer, the whole family is affected—this is something that affects everyone,” Panayiotou said. “That’s why the Super Bowl matters, because if we deliver what the research has said, which is that this gives people hope and belief on something that affects most everyone, then it’s a successful piece of communication.”

Pfizer and the ad will be featured on CBS’ Good Morning America the Monday after the game, with the spot running on CBS, TikTok, YouTube, Facebook and Instagram through Feb. 16.

For the latest Super Bowl 58 advertising news—who’s in, who’s out, teasers, full ads and more—check out Adweek’s Super Bowl 2024 Ad Tracker and the rest of our stories here. And join us on the evening of Feb. 11 for the best in-game coverage of the commercials.